1. Hallmarks of Aging: An Expanding Universe This updated review expands the original framework to 12 hallmarks of aging, adding dysregulated autophagy, chronic inflammation, and dysbiosis while incorporating the latest evidence. It explains how targeting these hallmarks could delay or prevent many age-related diseases simultaneously. https://www.cell.com/cell/fulltext/S0092-8674(2...
2. Geroscience: Linking Aging to Chronic Disease This review presents the Geroscience Hypothesis: aging is the major risk factor for most chronic diseases, and interventions that slow biological aging may reduce the incidence of cardiovascular disease, cancer, diabetes, dementia, kidney disease, and other age-related conditions at the same time. https://pubmed.ncbi.nlm.nih.gov/25417146/
3. From discoveries in ageing research to therapeutics for healthy ageing This comprehensive review summarizes the biology of aging, including cellular senescence, mitochondrial dysfunction, epigenetic alterations, stem cell exhaustion, and inflammation. It reviews emerging therapies, such as senolytics, partial epigenetic reprogramming, and metabolic interventions, that aim to extend healthspan by targeting aging itself. https://www.nature.com/articles/s41586-019-1365-220h ago1 like
1. Hallmarks of Aging: An Expanding Universe
This updated review expands the original framework to 12 hallmarks of aging, adding dysregulated autophagy, chronic inflammation, and dysbiosis while incorporating the latest evidence. It explains how targeting these hallmarks could delay or prevent many age-related diseases simultaneously.
https://www.cell.com/cell/fulltext/S0092-8674(2...
2. Geroscience: Linking Aging to Chronic Disease
This review presents the Geroscience Hypothesis: aging is the major risk factor for most chronic diseases, and interventions that slow biological aging may reduce the incidence of cardiovascular disease, cancer, diabetes, dementia, kidney disease, and other age-related conditions at the same time.
https://pubmed.ncbi.nlm.nih.gov/25417146/
3. From discoveries in ageing research to therapeutics for healthy ageing
This comprehensive review summarizes the biology of aging, including cellular senescence, mitochondrial dysfunction, epigenetic alterations, stem cell exhaustion, and inflammation. It reviews emerging therapies, such as senolytics, partial epigenetic reprogramming, and metabolic interventions, that aim to extend healthspan by targeting aging itself.
https://www.nature.com/articles/s41586-019-1365-2 20h ago 1 like