'Exceeded Our Expectations': One Antioxidant Could Be Key to Keeping Aging Muscles Strong
SparklyMcSparklesson Summary: Sarcopenia is the technical term for age-related muscle loss, which can start from your 30s and tends to accelerate from your 60s. It leads to difficulties common in senior citizens, including problems walking and a higher risk of falls and accidents. Hepatocyte growth factor (HGF), is a protein that helps activate muscle repair. HGF undergoes a damaging chemical process called nitration as the years tick by, breaking the key muscle repair signal. Now we may have one way of helping the body resist that decline. Researchers tested two compounds designed to counter the effects of nitration via antioxidants: glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS). LASSS stood out: Not only did it block nitration damage, it also made the protein twice as effective at connecting with the cells (via a receptor called c-met) that muscle repair processes rely on. The experiments showed that the compound was indeed effective at reducing nitration induced by muscle disuse. This still needs to be tested and verified in human muscles, but the early signs are promising. Aug 8 9 likes
Ethereal-Throne What are the best ways for a person to integrate these into their daily consumption ? Aug 8 2 likes
predat3d Do mere alpha lipoic acid and a Sulphur source like MSM have beneficial effects? Aug 8 4 likes
Sorin61 Author https://www.nature.com/articles/s41598-026-60835-w Aug 8 1 like